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-Before beginning treatment, the patient must follow a suitable cholesterol-lowering system that it will continue for the duration of the treatment.
-The dosage will be adapted according to the therapeutic objective and the response of the patient, based on the recommendations in force.
-The recommended initial dose is 5 or 10 mg once daily oral as well naïve patients and patients previously treated with another inhibitor of HMG - CoA reductase. For a given patient, the choice of the initial dose should be considered in the rate of LDL - C, potential cardiovascular risk and the risk of adverse.
-An increase in dosing the dose can be done after 4 weeks if need be (see pharmacodynamics).
-Having regard to the increase in the number of adverse effects observed at a dose of 40 mg compared to the lower doses (see adverse reactions), a maximum of 40 mg (2 times 20 mg) dose not will be considered that in patients with hypercholesterolemia severe with high cardiovascular risk (particularly those with a familial hypercholesterolemia) who has not reached the therapeutic target set at a dose of 20 mg / day and that will be the subject of regular monitoring (see section) (warnings and precautions). It is recommended that the opinion of a specialist be taken at the initiation of a dose 40 mg.
-CRESTOR can be administered at any time of the day, regardless of the meal.
-Pediatric use:
In children, effectiveness and job security are not established, the experience is limited to a small number of children (aged 8 years or more) with homozygous familial hypercholesterolemia. As a result, CRESTOR is not recommended in children at the present time.
-Use in the elderly subject:
. An initial dose of 5 mg is recommended in patients > 70 years (see warnings and precautions for use).
. No other age therapeutic adjustment is necessary.
-Dosage in the insufficient renal:
. For mild renal insufficiency to moderate, no dosage adjustment is necessary.
. An initial dose of 5 mg is recommended in patients with moderate renal impairment (creatinine clearance < 60 ml/min).
. The 40 mg dose is also contraindicated in patients with moderate renal impairment.
. In severe renal failure, all CRESTOR assays are contraindicated (see contraindications and pharmacokinetic properties).
-Liver in the insufficient dosage:
. In patients with Child-Pugh score < = 7, no increase in systemic exposure to rosuvastatin has been observed.
. In patients with a score of Child-Pugh of 8 or 9: an increase in systemic exposure to rosuvastatin were observed (see pharmacokinetics). In these patients a renal function evaluation will be carried out (see warnings and precautions for use).
. In patients with a score of Child-Pugh > 9: no data is available.
. CRESTOR is contraindicated in patients with active liver disease (see contraindications).
-Race:
An increase in systemic exposure was observed in Asian subjects (see guard and precautions and pharmacokinetic properties). An initial dose of 5 mg is recommended for patients with Asian origins. The 40 mg dose is contraindicated in those patients (see contraindications and pharmacokinetic properties).
-Dosage in patients with myopathy predisposing factors:
The recommended initial dose is 5 mg in patients with predisposing myopathy (see warnings and precautions for use).
The 40 mg dose is contraindicated in those patients (see contraindications).

Crestor treats high cholesterol and atherosclerosis, it is a drug from class of statins.

Rosuvastatin is a cholesterol-lowering medication that blocks the production of cholesterol (a type of fat) in the body. It works by reducing levels of "bad" cholesterol and triglycerides in the blood, while increasing levels of "good" cholesterol.